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kapB [2018-01-11 09:48:08]
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kapB [2018-01-11 09:48:08]

activator of [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|KinB], control of the [SW|phosphorelay]
locus
BSU31460
pI
6.82
mw
14.53 kDa
protein length
128 aa Sequence Blast
gene length
384 bp Sequence Blast
function
control of [SW|sporulation] initiation
product
activator of [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|KinB] in the initiation of [SW|sporulation]
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.2|Proteins controlling the activity of the kinases]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.2|Proteins controlling the activity of the kinases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,231,399 → 3,231,785

    The protein

    Structure

  • [PDB|1Y71] (from B. cereus, 61% identity)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|kinB]-[gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]
    description
    [Pubmed|8497199]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8497199], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|12618455], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [regulon|stringent response|stringent response]: positive regulation, [Pubmed|23378509], in [regulon|stringent response|stringent response]
  • [protein|5A6FBAE6553343092862CB79E150F934978C32A9|SinR]: repression, [pubmed|29321771], in [regulon|5A6FBAE6553343092862CB79E150F934978C32A9|SinR regulon]

    • regulation

  • induced upon addition of decoyinine (positive [SW|stringent response]) [Pubmed|23378509]
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    Biological materials

    Mutant

  • BKE31460 (Δ[gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCATCACCTCGCAT, downstream forward: _UP4_TAACCCAGTCTGACAAAAGA
  • BKK31460 (Δ[gene|18867F99B039D20DBCF004BC72E35CF0AE8FE467|kapB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31460 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCATCACCTCGCAT, downstream forward: _UP4_TAACCCAGTCTGACAAAAGA

    • References

  • 9426145,12618455,8497199,7592498